水溶性药物脂质体制备方法的研究进展

王荷逸, 黄思凡, 王邦国, 武鑫, 陈建明

中国药学杂志 ›› 2020, Vol. 55 ›› Issue (23) : 1935-1938.

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中国药学杂志 ›› 2020, Vol. 55 ›› Issue (23) : 1935-1938. DOI: 10.11669/cpj.2020.23.006
综述

水溶性药物脂质体制备方法的研究进展

  • 王荷逸1, 黄思凡2, 王邦国3, 武鑫1,3, 陈建明1*
作者信息 +

Progress on Preparation Method of Water-Soluble Drug Liposomes

  • WANG He-yi1, HUANG Si-fan2, WANG Bang-guo3, WU Xin1,3, CHEN Jian-ming1*
Author information +
文章历史 +

摘要

根据目前水溶性药物易泄漏、包封率低的不足,查阅近几年国内外相关文献,对其制备方法进行综述。总结水溶性药物脂质体制备方法的研究进展,为水溶性药物脂质体制备提供参考。脂质体包载水溶性药物在实验室研究中已取得不错的成果,但大工业生产较困难,还需深入研究。

Abstract

To summarize the research progress of the preparation methods of water-soluble drug liposomes and provide reference for the preparation of water-soluble drug liposomes. According to the current shortcomings of easy leakage of water-soluble drugs and low encapsulation rate, the preparation methods of water-soluble drugs were reviewed by referring to relevant literatures in recent years. Liposome-encapsulated water-soluble drug has achieved good results in laboratory research, but it is difficult to produce in large industry, and further research is needed.

关键词

水溶性药物 / 脂质体 / 制备方法

Key words

water-soluble drug / liposome / preparation method

引用本文

导出引用
王荷逸, 黄思凡, 王邦国, 武鑫, 陈建明. 水溶性药物脂质体制备方法的研究进展[J]. 中国药学杂志, 2020, 55(23): 1935-1938 https://doi.org/10.11669/cpj.2020.23.006
WANG He-yi, HUANG Si-fan, WANG Bang-guo, WU Xin, CHEN Jian-ming. Progress on Preparation Method of Water-Soluble Drug Liposomes[J]. Chinese Pharmaceutical Journal, 2020, 55(23): 1935-1938 https://doi.org/10.11669/cpj.2020.23.006
中图分类号: R944   

参考文献

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基金

国家自然科学基金项目资助(81772749);上海市青年科技启明星计划资助(18QB1400400);上海市科技小巨人工程项目资助(1902HX76600);上海青浦区产学研合作发展资金项目资助(青产学研2019-5)
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